Treatment of Dwarfism With Recombinant Human Insulin-Like Growth Factor-1
نویسندگان
چکیده
منابع مشابه
Treatment of dwarfism with recombinant human insulin-like growth factor-1.
BACKGROUND The growth hormone-IGF (insulin-like growth factor) system plays a central role in hormonal growth regulation. Recombinant human (rh) growth hormone (GH) has been available since the late 1980s for replacement therapy in GH-deficient patients and for the stimulation of growth in patients with short stature of various causes. Growth promotion by GH occurs in part indirectly through th...
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OBJECTIVE To evaluate the safety and tolerability of recombinant human insulin-like growth factor 1 (rhIGF-1) complexed with IGF binding protein 3 (rhIGF-1/rhIGFBP-3) in patients with myotonic dystrophy type 1 (DM1). DESIGN Open-label dose-escalation clinical trial. SETTING University medical center. PARTICIPANTS Fifteen moderately affected ambulatory participants with genetically proven ...
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ژورنال
عنوان ژورنال: Deutsches Aerzteblatt Online
سال: 2009
ISSN: 1866-0452
DOI: 10.3238/arztebl.2009.0703